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4 edition of Genomic alterations in prostate high grade intraepithelial neoplasia (HPIN) can be predictive of a more aggressive disease process found in the catalog.

Genomic alterations in prostate high grade intraepithelial neoplasia (HPIN) can be predictive of a more aggressive disease process

Jaudah Al-Maghrabi

Genomic alterations in prostate high grade intraepithelial neoplasia (HPIN) can be predictive of a more aggressive disease process

by Jaudah Al-Maghrabi

  • 18 Want to read
  • 33 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 2001.

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL19508490M
ISBN 10061258691X
OCLC/WorldCa52575165

High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely pre-invasive stage of adenocarcinoma, a decade after its first formal description. PIN has a high predictive value as a marker for adenocarcinoma, and its identification warrants repeat BACKGROUND High‐grade prostate intraepithelial neoplasia (PIN) is the most likely precursor of prostate adenocarcinoma. However, the relationship between this lesion and prostate cancer has not yet been established. The detection of cytogenetic changes in the lesions prior to prostate adenocarcinoma would be useful in demonstrating such a pathogenic relationship. METHODS Twenty eight high

  High-grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostate adenocarcinoma, but the frequency and timing of epigenetic changes found in prostate carcinogenesis has not been extensively documented. Thus, the promoters of three genes (APC, GSTP1, and RARβ2) involved in prostate carcinogenesis were tested by quantitative methylation-specific PCR in tissue   Foamy gland high-grade prostatic intraepithelial neoplasia. Am J Surg Pathol – [Google Scholar] Argani, P. and J. I. Epstein. Inverted (Hobnail) high-grade prostatic intraepithelial neoplasia (PIN): report of 15 cases of a previously undescribed pattern of high-grade PIN. Am J Surg Pathol – [Google ()[PINRA]

Atypical intraepithelial lesions (AILs) with sparse basal cell layers and simple architectural patterns (flat, tuft, and micropapillary) in close association with a Gleason 3 (G3) invasive prostate cancer (iPCa) pattern (low-grade prostatic intraepithelial carcinoma [PIC] or low-grade carcinoma in situ, or high-grade prostatic intraepithelial areas of high-grade prostatic intraepithelial neoplasia (HG-PIN) by 6 months of age (Figures 1C, 1E, and S1I). Importantly, the histologic phenotype of HG-PIN in PtenL/+;R26FV mice was distinct, characterized by a striking degree of nuclear atypia compared with the rarer HG-PIN with minimal atypia in PtenL/+ control mice (Figures 1D, 1E, 1H (17)


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Genomic alterations in prostate high grade intraepithelial neoplasia (HPIN) can be predictive of a more aggressive disease process by Jaudah Al-Maghrabi Download PDF EPUB FB2

BACKGROUND: Although high grade prostatic intraepithelial neoplasia (HGPIN) is considered a neoplastic lesion that precedes prostate cancer (PCA), the genomic structures of HGPIN remain unknown. OBJECTIVE: Identification of the genomic landscape of HGPIN and the genomic differences between HGPIN and PCA that may drive the progression to :// Prostatic intraepithelial neoplasia (PIN) is defined as a neoplastic growth of epithelial cells within preexisting prostatic acini or ducts.

Of the PINs, high grade PIN (high grade prostatic intraepithelial neoplasia [HGPIN], grade 2–3) is considered to be a precursor for PCA development. Table 2 – Summary of comparison data between high grade intraepithelial neoplasia and prostate cancer genomes HGPIN, median (quartiles) PCA, median (quartiles) p value Somatic mutation number (, 14) (28, 39) (15)/pdf.

High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20– an autopsy study of cases.

In Vivo 8: – PubMed Google Scholar High-grade prostatic intraepithelial neoplasia (PIN) is accepted as a premalignant lesion that has the potential to progress to prostate adenocarcinoma. 1–16 Prostatic intraepithelial neoplasia is the abnormal proliferation within the prostatic ducts of premalignant foci of cellular dysplasia and carcinoma in situ without stromal invasion /prostatic-intraepithelial-neoplasia.

Cancer is a genetic disease, and its emergence and progression are evolutionally driven by alterations to the genetic material of the cell.

A putative precursor lesion of prostate cancer (PCA) is high‐grade prostatic intraepithelial neoplasia (HGPIN), a proliferation of the atypical secretory epithelium confined to the prostate's pre‐existing glands or ://   High-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely precursor of prostatic adenocarcinoma according to virtually all available evidence.

This lesion is characterized by   This Review discusses the morphologic spectrum and clinical importance of proposed preneoplastic lesions and conditions of the prostate, especially high-grade prostatic intraepithelial ://   MOLECULAR AND GENETIC ALTERATIONS.

More than 50 genetic and molecular abnormalities have been associated with HGPIN. At least 10 of these changes are reported in both HGPIN and prostate cancer [].In addition, more than 36 genetic and molecular alterations are intermediate between normal prostate and prostate cancer [].This has led to multiple studies making the conclusion that "High-grade   This chapter describes the most common techniques of molecular cytogenetics, such as fluorescence in situ hybridization (FISH) and comparative genomic Molecular analysis has shown that high grade PIN and prostate cancer share many genetic abnormalities.[4] This has been confirmed in a transgenic mouse model.

The risk for men with high grade PIN of being diagnosed with prostate cancer after repeat biopsy has decreased since the introduction of biopsies at more than six locations (traditional ?f=35&m= Abstract: High-grade intraepithelial neoplasia (HGPIN) is a lesion which is widely believed to be a precursor of prostatic adenocarcinoma.

Correct morphologic identification of HGPIN and an High-grade prostatic intraepi thelial neoplasia (HGPIN) has been established as a pre- cursor to prostatic adenocarcinoma. HGPIN shares many morphological, genetic, and /   Noncancerous growth of the cells lining the internal and external surfaces of the prostate gland.

Having high-grade prostatic intraepithelial neoplasia may increase the risk of developing prostate /cancer-terms/def/prostatic-intraepithelial-neoplasia.

staining for distinguishing high-grade PIN from intraductal carcinoma of the prostate on needle biopsy. Am J Surg Pathol ; – [13] Park K, Dalton JT, Narayanan R, et al. TMPRSS2:ERG gene fusion predicts subsequent detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia.

J Clin Oncol ; 32 (15)/pdf/shifting-paradigms. Various findings in prostate tissue indicate raised risk of later prostate cancer, and, of all these, the finding of high-grade prostatic intraepithelial neoplasia on repeated biopsy is most High-grade intraepithelial neoplasia (HGPIN) is a lesion which is widely believed to be a precursor of prostatic adenocarcinoma.

Correct morphologic identification of HGPIN and an understanding of how this diagnosis affects clinical management in the research setting are necessary as HGPIN is a premalignant lesion with many genetic alterations similar to prostate cancer, but is not yet New addition to the most recent WHO classification of urinary tumors and male genital organs (Moch: WHO Classification of Tumours of the Urinary System and Male Genital Organs, 4th Edition, ) Intraacinar or intraductal neoplastic epithelial proliferation that has some features of high grade prostatic intraepithelial neoplasia but exhibits much greater architectural or cytological atypia High grade prostatic intraepithelial neoplasia (HGPIN) is the precursor lesion to some forms of adenocarcinoma.

HGPIN should not be confused with intraductal carcinoma. The latter, even when isolated in a prostate biopsy, carries a predictive value of % for cancer in a repeat ://   Although high grade prostatic intraepithelial neoplasia (HGPIN) is considered a neoplastic lesion that precedes prostate cancer (PCA), the genomic structures of HGPIN remain fication of the genomic landscape of HGPIN and the genomic differences between HGPIN and PCA that may drive the progression to analyzed 20 regions of paired HGPIN and PCA.

prostate on subsequent prostate biopsy particularly those diagnosed with multi-focal HGPIN on initial biopsy so close follow-up of these patients is recom-mended. References [1] Montironi, R., Muzzucchelli, R., Lopez-Beltran, A., et al.

() Mechanisms of Disease: High Grade Prostatic Intraepithelial Neoplasia and Other Proposed Pre-In all, we selected 33 promoter-associated novel CpG sites that were differentially methylated in high-grade prostatic intraepithelial neoplasia and PCa in comparison with benign prostate tissue Abstract.

High-grade intraepithelial neoplasia (HGPIN) is a lesion which is widely believed to be a precursor of prostatic adenocarcinoma. Correct morphologic identification of HGPIN and an understanding of how this diagnosis affects clinical management in the research setting are necessary as HGPIN is a premalignant lesion with many genetic alterations similar to prostate cancer, but is not